DMSO can contribute a carbon unit in selected organic reactions, in addition to serving as a solvent. One reported example is the preparation of 2-unsubstituted benzothiazoles using potassium sulfide and DMSO.
Different materials supply different atoms
In the reported chemistry, potassium sulfide is the sulfur source and DMSO is the carbon source. This distinction explains why the same reaction mixture can contain DMSO without assigning every atom-transfer role to it.
The contribution is specific to the reported transformation and substrate range. DMSO's presence in a different reaction is not enough to establish that its carbon enters the product.
Treat reagent consumption separately
For a proposed C1-source route, account for chemically consumed DMSO, by-products and separation. Compare product selectivity and the fate of unreacted material with alternative routes.
Assay, water and impurity limits should match the established reaction. Thermal behavior and compatibility need assessment for the full mixture. A laboratory reaction is a starting point for development, rather than evidence of commercial-scale adoption.
For sourcing, identify the C1-transfer step and share the DMSO specification with YUJI.
